Graviola Tincture (1 oz.)

Dried Leaf Extracted in 40% Organic Alcohol

Graviola also known as soursop can reduce blood pressure and decreases heart rate.

Research has shown it to be effective against;

• Multi-drug antiviral resistant cancer cells and demonstrated it is;
• Anti-tumorous
• Anti-bacterial
• Antifungal
• Effective against Herpes simplex
• Cellular protector
• Antimalarial
• Antidepressant
• Sedative
• Broad spectrum internal and external antimicrobial
• Uterine stimulant
• Aids lactation
• Reduces blood pressure
• Lowers heart rate
• reduces fevers, spasms, coughs

Usage suggestions: We recommend you read the Technical Data Report to determine the best dosage for your condition.

Most commonly 1 dropperful taken 3 times a day is used. Diluting it with water, juice, or other beverages helps to reduce the  strength of the organic vodka.

After long-term use Parkinson-like symptoms can occur which disappear after you stop taking graviola, therefore, to avoid these symptoms it is often recommended that after taking it for 3 months you stop for 1 month before resuming medication .

Other actions

• Insecticidal
• Antiviral
• Parasitic infections

*with long term use take a probiotic due to the strong antimicrobial properties, do not use when pregnant or while taking Coenzyme Q10. This statement has not been evaluated by the FDA.  This product is not intended to diagnose, treat, or cure or prevent any disease

 

Clinical Summary

    Derived from a tree in the rain forests of Africa, South America, and Southeast Asia. The bark, leaves, root, and fruits have been used as traditional remedies in many countries.

Extracts of graviola have been shown to have; antiviral (1), antiparasitic, antirheumatic, astringent, emetic (2), antileishmanial and cytotoxic (3) (4) effects.

Graviola has also been shown to be effective against multidrug resistant cancer cells line (5) (4). There are no large scale studies in humans on the effects of graviola.

Alkaloids extracted from graviola may cause neuronal dysfunction and degeneration leading to symptoms reminiscent of Parkinson’s Disease (6).top which will disappear aftering stopping usage.

Purported uses; Cancer treatment, Herpes Infections, Parasitic infections, Sedation.

Top Constituents; Acetogenins, quinolines, isoquinolines, annopentocins and annomuricins (7). Coreximine and reticuline subfractions have been isolated from root bark (6).

Top Mechanism of Action;

Annonaceous acetogenins, a phytochemical isolated from the leaves, bark and twigs of graviola, are thought to be the active ingredient. The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1). The ethyl acetate extract was found to be more active than the methanolic or hexanolic extracts. Extracts were shown to be effective against Leishmania braziliensis, L. panamensis promastigotes and the cancer cell line U 937 (3) and hepatoma cell lines(8) in vitro. Extracts were also shown to be lethal to the fresh-water mollusk Biomphalaria glabrata, which acts as a host for the parasitic worm Schistosoma mansoni (2).

Alkaloids from graviola have been shown to be detrimental to the survival of dopaminergic nerve cells in vitro. This may in turn lead to neuronal dysfunction and degeneration. Graviola-induced cell death was inhibited by the supplementation of glucose suggesting that cell death was caused by energy depletion (6).       

Graviola extracts have also been shown to be effective against the growth of Adriamycin resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking the cancer cell’s access to ATP and by inhibiting the actions of plasma membrane glycoprotein (5).

Graviola may also have antidepressant activity due to its ability to stimulate serotonin receptors (7).

Top Pharmacokinetics; Little is known about the absorption, distribution, metabolism or excretion of graviola.

Top Adverse Reactions; Graviola may cause movement disorders and myeloneuropathy with symptoms similar to Parkinson’s disease (6).

Top Literature Summary and Critique; There are no large scale studies in animals or humans on the effects of graviola.

References:

1 Padma P, Pramod NP, Thyagarajan SP, Khosa RL. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol. 1998;61:81-3.

2 dos Santos AF,.Sant’Ana AE. Molluscicidal properties of some species of Annona. Phytomedicine. 2001;8:115-20.

3 Jaramillo MC, Arango GJ, Gonzalez MC, Robledo SM, Velez ID. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia 2000;71:183-6.

4 Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ et al. New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata. J Nat.Prod. 2002;65:470-5.

5 Oberlies NH, Chang CJ, McLaughlin JL. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. J Med Chem. 1997;40:2102-6.

6 Lannuzel A, Michel PP, Caparros-Lefebvre D, Abaul J, Hocquemiller R, Ruberg M.Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord. 2002;17:84-90.

7 Roman G. Tropical myeloneuropathies revisited. Curr.Opin.Neurol 1998;11:539-44.

8 Chen JC, Tsai CC, Chen LD, Chen HH, Wang WC. Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats. Am.J Chin Med. 2000;28:175-85.

9 Graviola.org. http://www.graviola.org/cgi/gpp.cgi?000001-000001-000000&../../1graviola/parsed_pages/graviola-data.htm. Accessed November 2003.top mall Heading